Vaccinations : protection relative contre la maladie d’Alzheimer ?

Les vaccinations protègent-elles partiellement contre la maladie ou bien les personnes âgées qui se vaccinent ont-elles un profil de prévention meilleur ?

En tout cas, la Société Américaine de Gérontologie a considéré cette possibilité comme suffisamment sérieuse pour ajouter en 2021 les vaccinations dans la liste des facteurs protecteurs possibles de démences [1].

Références :

1. Gerontological Society of America National Adult Vaccination Program Workgroup. Lower Risk of Dementia Adds to Lengthy List of Reasons to Be Vaccinated. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1435.

https://academic.oup.com/biomedgerontology/article/76/8/1435/6320562?login=false

2. Wiemken TL, Salas J, Hoft DF, Jacobs C, Morley JE, Scherrer JF. Dementia risk following influenza vaccination in a large veteran cohort. Vaccine. 2021 Sep 15;39(39):5524-5531.
3. Kim JI, Zhu D, Barry E, Kovac E, Aboumohamed A, Agalliu I, Sankin A. Intravesical Bacillus Calmette-Guérin Treatment Is Inversely Associated With the Risk of Developing Alzheimer Disease or Other Dementia Among Patients With Non-muscle-invasive Bladder Cancer. Clin Genitourin Cancer. 2021 Dec;19(6):e409-e416
4. Scherrer J, Salas J, Jacobs C, Wiemken T. Lower dementia risk in patients vaccinated against herpes zoster. Ann Fam Med. 2022 Apr 1;(20 Suppl 1
5. Scherrer JF, Salas J, Wiemken TL, Jacobs C, Morley JE, Hoft DF. Lower Risk for Dementia Following Adult Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1436-1443.
6. Wiemken TL, Salas J, Morley JE, Hoft DF, Jacobs C, Scherrer JF. Comparison of rates of dementia among older adult recipients of two, one, or no vaccinations. J Am Geriatr Soc. 2022 Apr;70(4):1157-1168.
7. Ali E, Shaikh A. Influenza vaccination and dementia risk; an unanticipated benefit? Ann Med Surg (Lond). 2022 Jul 19;80:104187.
8. Wu X, Yang H, He S, Xia T, Chen D, Zhou Y, Liu J, Liu M, Sun Z. Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies. Front Immunol. 2022 May 3;13:872542.
9. Veronese N, Demurtas J, Smith L, Michel JP, Barbagallo M, Bolzetta F, Noale M, Maggi S. Influenza vaccination reduces dementia risk: A systematic review and meta-analysis. Ageing Res Rev. 2022 Jan;73:101534
10. Scherrer JF, Salas J, Wiemken TL, Hoft DF, Jacobs C, Morley JE. Impact of herpes zoster vaccination on incident dementia: A retrospective study in two patient cohorts. PLoS One. 2021 Nov 17;16(11):e0257405.
11. Weinberg MS, Zafar A, Magdamo C, Chung SY, Chou WH, Nayan M, Deodhar M, Frendl DM, Feldman AS, Faustman DL, Arnold SE, Vakulenko-Lagun B, Das S. Association of BCG Vaccine Treatment With Death and Dementia in Patients With Non-Muscle-Invasive Bladder Cancer. JAMA Netw Open. 2023 May 1;6(5):e2314336.